careworn, drawn, haggard, raddled, worn -- (showing the wearing effects of overwork or care or suffering; "looking careworn as she bent over her mending"; "her face was drawn and haggard from sleeplessness"; "that raddled but still noble face"; "shocked to see the worn look of his handsome young face"- Charles Dickens)
bony, cadaverous, emaciated, gaunt, haggard, pinched, skeletal, wasted -- (very thin especially from disease or hunger or cold; "emaciated bony hands"; "a nightmare population of gaunt men and skeletal boys"; "eyes were haggard and cavernous"; "small pinched faces"; "kept life in his wasted frame only by grim concentration")