despair, desperation -- (a state in which all hope is lost or absent; "in the depths of despair"; "they were rescued from despair at the last minute"; "courage born of desperation")
despair -- (the feeling that everything is wrong and nothing will turn out well; "they moaned in despair and dismay"; "one harsh word would send her into the depths of despair")
Overview of verb despair
The verb despair has 1 sense
despair -- (abandon hope; give up hope; lose heart; "Don't despair--help is on the way!")