isolation -- (a state of separation between persons or groups)
isolation -- (a feeling of being disliked and alone)
isolation, closing off -- (the act of isolating something; setting something apart from others)
isolation -- ((psychiatry) a defense mechanism in which memory of an unacceptable act or impulse is separated from the emotion originally associated with it)
isolation -- (a country's withdrawal from international politics; "he opposed a policy of American isolation")