nescient, unbelieving -- (holding that only material phenomena can be known and knowledge of spiritual matters or ultimate causes is impossible)
ignorant, nescient, unlearned, unlettered -- (uneducated in general; lacking knowledge or sophistication; "an ignorant man"; "nescient of contemporary literature"; "an unlearned group incapable of understanding complex issues"; "exhibiting contempt for his unlettered companions")