plague, pestilence, pest, pestis -- (a serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of a flea that has bitten an infected animal)
plague, pestilence, pest -- (any epidemic disease with a high death rate)
infestation, plague -- (a swarm of insects that attack plants; "a plague of grasshoppers")
plague -- (any large scale calamity (especially when thought to be sent by God))
plague -- (an annoyance; "those children are a damn plague")
Overview of verb plague
The verb plague has 2 senses
blight, plague -- (cause to suffer a blight; "Too much rain may blight the garden with mold")